Evidence is mounting that cannabidiol has many beneficial properties. It is one of more than 500 components in Cannabis sativa, and also one of 120 phytocannabinoids. There is great interest in cannabidiol in research centers all over the globe. This compound is useful in many ways. It can be used to make cosmetics for skin, nails, and hair, as well as preparations that support immunity and prevent or treat various diseases.
Cannabidiol’s uniqueness lies in its multidirectional action and mechanism. Despite its biological activity, it is not psychotropic, does not induce an addiction, and is not intoxicating. Numerous scientific studies have shown that CBD can be used to reduce anxiety, sedate and protect the brain. It has antispasmodic and antiemetic properties.
This compound can be used to help treat nicotine and alcohol addiction (Russo 2011, Morgan 2019,). The first double-blind, randomized, placebo-controlled clinical trial, published in 2017 in New England Journal of Medicine, proved that it is an effective antiepileptic agent. The results showed that cannabidiol reduces seizures in children and adults suffering from refractory Dravet Syndrome, also known as severe meoclonic epilepsy (SME) in infants. Another study that involved patients with Lennox–Gastaut syndrome was also published (EA Thiele and “Lancet”, vol. 391, March 17, 2018, O. Devinsky (New England Journal of Medicine, 2018) found that cannabidiol decreases seizures including atonic seizures and improves patients’ general health compared with placebo. The innovative CBD capsules, which are gastro-resistant and contain CBD, were discovered to have a significant effect on epilepsy in children suffering from drug-resistant epilepsy by Israeli researchers in 2019.
It must be safe and well-tolerated. However, it must come from reliable sources
Cannabidiol has been shown to be safe and well-tolerated according to research. It has only a few mild side effects. People may experience rash, fatigue and sleepiness. Without consulting your doctor, pharmacist, or other healthcare professionals, do not exceed 70 mg/day. This is the recommended daily intake for healthy individuals.
Some medications may interact with CBD, so it is important that people who are suffering from depression, epilepsy, or other oncological conditions consult their doctors before taking CBD products. The US Food and Drug Administration (FDA) recommends abstaining from CBD products during pregnancy or breastfeeding.
Sublingual oils are the most common form of cannabidiol. People may also heat dried CBD to release active substances. Studies (J. Atsmon “Clinical Pharmacology in Drug Development”, 2017, 2017) have shown that gastro-resistant capsules containing micellets are the best form for pharmacokinetic parameters. These capsules offer a 3.5-fold higher bioavailability than standard oral CBD oil.
The manufacturing process of dietary supplements is crucial. Therefore, you need to ensure that the preparation meets GMP (Good Manufacturing Practices) standards. This will prove the product’s high quality. You should be careful about the composition of CBD products that are designated as dietary supplements. It should not contain psychotropic THC. Cannabidiol preparations should only be purchased from a licensed pharmacy. Only then can they be sold by a manufacturer that has tested them thoroughly before releasing them on the market.
COVID-19 has demonstrated strong anti-inflammatory properties of Cannabidiol
Internationally, CBD is known for its anti-inflammatory properties. This relationship is being explored and used more frequently. For example, in the treatment patients with Crohn’s disease and ulcerative colitis (Carvalho 2020). As well as in dermatology, e.g. Palmieri 2019, in patients with atopic dermatology, among others. It is also being considered for use in treating neurodegenerative disorders of the central nervous systems, such as prion disease, which is characterized by the accumulation pathological prion proteins in various brain structures. Cannabidiol inhibited the growth of pathological prion protein in infected cells (animal study), and prolonged their survival.
Recent research has increased attention to the anti-inflammatory effects of this substance. A study published in Nature by Israeli scientists was designed to examine the effects of cannabis on markers of immune response in COVID-19. The levels of interleukins 6, and 8, responsible for the formation so-called a “cytokine storm”, were significantly decreased by Cannabis sativa extract. Scientists who studied the effects three compounds from cannabis (CBG, THCV) have concluded that they had a significant impact on interleukins 6 and 8. These interleukins are responsible for the formation of the so-called cytokine storm. Scientists who have studied the effects of three compounds isolated from cannabis, i.e. CBD, CBG, and THCV, found that they could reduce the production of pro-inflammatory cytokines within lung epithelial cell cells. CBD was given a particularly positive rating, which suggests that it might have more effective activity in reducing the severity of pneumonia. Although additional research is required to allow cannabis to be used for the treatment of COVID-19 patients, the existing research (e.g. The American study that examined the effects of CBD on increasing apelin concentrations – offers hope for finding a drug that reduces the death risk from severe COVID-19 pneumonia.